As an artist she began making prints in 1978 under the tutelage of William Wimmer. Miss Niffenegger trained as a visual artist at the School of the Art Institute of Chicago, and received her MFA from Northwestern University’s Department of Art Theory and Practice in 1991. She has exhibited her artist’s books, prints, paintings, drawings and comics at Printworks Gallery in Chicago since 1987.
Her first books were printed and bound by hand in editions of ten. Two of these have since been commercially published by Harry N. Abrams: The Adventuress and The Three Incestuous Sisters.